Joseph Michael Falcone, Ph.D.

Associate Professor & Chairperson

Division of Natural Sciences and Mathematics

 Keystone College

One College Green

La Plume, Pennsylvania 18440

 

     office: (570) 945-8413

home: (570) 586-6555

E-mail: joe.falcone@keystone.edu

 

Education:

 

Degree           Year                            Field                                       School           

 

Ph.D.              1997                           Biophysics   State University of New York at Buffalo

                                                                                    Roswell Park Memorial Cancer Institute                                                                                                  Graduate Division, Buffalo, New York 

 

B.S.                 1989                           Physics         Manhattan College, Riverdale, New York

 

B.A.                 1989                           Philosophy  Manhattan College, Riverdale, New York

           

           

 

Professional Appointments:

 

2006-Present: Division Chairperson, Natural Science and Mathematics, Keystone College

 

2004-Present: Associate Professor, Natural Science and Mathematics, Keystone College

 

2000-Present: Curriculum Coordinator for Biological Science and Health Science,

  Natural Science and Mathematics, Keystone College

 

2000 -2004:   Assistant Professor, Natural Science and Mathematics, Keystone College

 

1998-2000:    Assistant Professor, Department of Physics, East Tennessee State University, Johnson City, TN

 

1995-1998:    Postdoctoral Research Fellow, Department of Experimental Radiation Oncology,

Wake Forest University School of Medicine, Winston-Salem, NC

 

1992-1995:    Adjunct Instructor, Biochemistry, D'Youville College, Buffalo, NY

 

1989-1995:    Doctoral Research Fellow, Department of Biophysics, Roswell Park Memorial Cancer Institute, State University of New York at Buffalo, Buffalo NY


                       

                                               

Honors:

 

Professional:             Phi Theta Kappa, Honorary Faculty Inductee, 2007

 

Who’s Who in College Teaching, Keystone College, 2002-2006

 

Faculty of the Month, Keystone College, January 2002

                       

Postgraduate:            Radiation Research Society Young Investigator

                                    Radiation Research Society 45th Annual Scientific Meeting

                                    Providence, Rhode Island, May 3-7, 1997

                                               

 

 Graduate:                  Research Fellow

                                    Experimental Radiation Oncology

                                    Wake Forest University School of Medicine, 1996-1997

 

NORCUS/AWU  Research Fellowship

                                    U.S. Department of Energy Fellow

                                    Battelle, Pacific Northwest National Laboratories

                                    United States Department of Energy

                                    February 1992 - September 1994

 

                                    Research Fellow

                                    Roswell Park Memorial Cancer Institute

                                    Department of Biophysics

                                    August 1989 - 1996

 

Undergraduate:         Baccalaureate cum laude

                                    Epsilon Sigma Pi Honor Society - Liberal Arts

                                    Sigma Pi Sigma Honor Society – Physics

                                    Sigma Xi

 

 

Teaching Experience:

 

General Physics I Lecture

General Physics II Lecture

General Chemistry I Lecture

General Chemistry II Lecture

General Physics I and II Labs

General Chemistry I and II Labs

Organic Chemistry I Lecture

Organic Chemistry II Lecture

Instrumental Analysis Lecture and Lab

Organic Chemistry I and II Labs

Calculus I

College Algebra

Senior Seminar and Research

Introduction to College Seminar

Senior Capstone

Biophysics

 

 

 

 

Curriculum Development: 

 

Developed Baccalaureate program in Biology with concentrations in:

  • General Biology
  • Forensic Biology
  • Environmental Biology
  • Pre-Medical Professions; with articulation agreements with area universities for Pharmacy, Physical Therapy, Physician Assistant, and Chiropractic graduate programs.

 

Developed Associate programs in Health Science and articulation agreements with area universities for:

  • Nursing
  • Occupational Therapy
  • Radiation Therapy
  • Radiological Technology & Diagnostic Imaging
  • Medical Technology
  • Cardiac Perfusion

 

Assisted in the development of Baccalaureate programs in Environment, and Mathematics Education. 

 

Grant Experience:

 

2004:  Analytical Instrumentation and Academic Technology for Keystone College’s Biology and Environment programs. Funding source: United States Department of Education, Co-PI, The project funded the purchase of a Varian 1200L GC/LC/Mass Spectrometer, a Varian ICP-OEM optical emission spectrometer, a Varian HPLC system, a Cary Fluorescence spectrophotometer, a Cary UV-Vis spectrophotometer and computers for the Analytical Laboratory. 

Funding amount:  $400,000

 

2003: Purchase of an HPLC system for the chemistry laboratory.  Funding source: The Pittsburgh Conference.

Funding amount: $9000

2000: Technology in the Science Classroom: Implementing the Vision of the Tennessee Science Standards. Funding source: Tennessee Higher Education Commission.  The project trained twenty middle and high school science teachers on how to more effectively use technology as a scientific tool for data acquisition, modeling, and improved student learning. Funding amount: $43,000

 

Research Experience:                 

 

 

  • Analysis and quantification of DNA base damage, nucleoside damage, and nucleobase-amino acid crosslink products arising from reactions of ionizing radiation and/or reactive oxygen species with DNA, or DNA and  protein model compounds, utilizing the techniques of gas chromatography/electron impact mass spectrometry (GC/MS) and high performance liquid chromatography (HPLC).
  • Methods development for GC/MS sample preparation and oxygen free sample derivitization techniques.
  • DNA isolation from cell culture and tumor tissue isolates.
  • Methods development for sensitive detection of DNA damage by 32P postlabeling and thin layer chromatography (TLC)  involving enzyme kinetics studies of P1 nuclease and T4 polynucleotide kinase.
  • Mathematical modeling of the hydrolytic degradation of a DNA oligomer by an endonuclease.
  • DNA oligomer damaged product identification by one and two dimensional proton nuclear magnetic resonance spectroscopy (NMR) utilizing 400 and 600MHz systems.   
  • Three dimensional modeling of proteins and nucleic acids by molecular mechanics and molecular dynamics. 
  • Crystallization of nucleic acids and  proteins. 
  • Electron spin resonance spectroscopy (ESR) and electron-nuclear double resonance spectroscopy (ENDOR) of single crystals of nucleic acids or analog compounds utilizing a V-band tuned cavity instrument.

 

Publications:

 

Falcone, J.M., Becker, D., Sevilla, M.D., Swarts, S.G., (2005) “Products of the reactions of the dry and aqueous electron with hydrated DNA: hydrogen and 5,6-dihydropyrimidines”, Radiation Physics and Chemistry, Volume 72, Issues 2-3, Pages 257-264 Christiane Ferradini Memorial Issue

 

Falcone, J.M., Box, H.C., (1997), “Selective hydrolysis of damaged DNA by nuclease P1 “, Biochemica et Biophysica Acta 1337: 267-275

 

Razskazovskii,Y., Swarts, S.G.,  Falcone, J.M., Taylor, C., Sevilla, M.D., (1997),  Competitive Electron Scavenging by Chemically Modified Pyrimidine Bases in Bromine-Doped DNA: Relative Efficiencies and Relevance to Intrastrand Electron Migration Distances”, Journal of Physical Chemistry B,  101 (8),  1460-1467

 

Falcone, J.M., Box, H.C., Miller, J.H.,” Catalytic Activity of Nuclease P1: Experiment and Theory” Radiation Damage in DNA:Structure/Function Relationships at Early Times(Eds. A.F. Fuciarelli, J.H.Miller, J.D. Zimbrick) Columbus, OH, Battelle Press, 1994, pp 346-353

 

Professional Organizations:

           

Radiation Research Society

American Chemical Society

American Association of Physics Teachers

American Association of University Professors

 

Community Service:

 

Abington Little League: Board Member

Abington Little League: Fundraising Committee

Abington Little League: T-Ball Commissioner

Abington Little League: Junior League Head Coach

Abington Youth Soccer League: Coach